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Charcot Marie Tooth inheritance

Charcot-Marie-Tooth disease: MedlinePlus Genetic

  1. Charcot-Marie-Tooth disease encompasses a group of disorders called hereditary sensory and motor neuropathies that damage the peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound
  2. Charcot-Marie-Tooth Disease (CMT) X-linked inheritance means that the genetic defect (or mutation) is located on the X chromosome. In females, who have two X chromosomes, a normal copy of the gene on one chromosome can often compensate (at least partially) for the defective copy. Therefore, X-linked diseases usually affect males more.
  3. ant, an autosomal recessive, or X-linked manner. These are a few of the ways a disorder or trait can be passed down through a family
  4. ant, though there also are X-linked and autosomal recessive subtypes
  5. ant, autosomal recessive, and X-linked, all of which are tied to a person's chromosomes. Each person has 23 pairs of chromosomes
  6. ant, autosomal recessive, or X-linked manner. People get two copies of most of their genes. One copy comes from their mothers and the other copy comes from their fathers
  7. ant, autosomal recessive, X-linked do

Charcot-Marie-Tooth disease is an inherited, genetic condition. It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms. Sometimes, these mutations damage the nerves. Other mutations damage the protective coating that surrounds the nerve (myelin sheath) Inheritance patterns. Humans have about 22,000 genes. These are grouped together on 23 paired chromosomes: 23 single chromosomes from your mother and 23 from your father. And, apart from the sex cells - sperm and unfertilised eggs - every single human cell has a full copy of these 46 chromosomes in 23 pairs

Causes/Inheritance - Charcot-Marie-Tooth Disease (CMT

Inheritance of Charcot-Marie-Tooth Disease Charcot-Marie-Tooth (CMT) disease is a group of genetic disorders that cause defects in the myelin sheaths (the insulating material that prevents the loss of electrical signals as they travel along nerve fibers), or the axons themselves (the nerve cell extension), in the peripheral nervous system Charcot-Marie-Tooth disease type 1A (CMT1A) is a type of inherited neurological disorder that affects the peripheral nerves. People with this disease experience weakness and wasting (atrophy) of the muscles of the lower legs beginning in adolescence; later they can also have hand weakness and sensory loss

Inheritance: How is Charcot-Marie-Tooth disease inherited

Charcot-Marie-Tooth disease is a large group of clinically and genetically heterogeneous disorders characterized by progressive motor and sensory polyneuropathy. These can be separated (with overlap) into two large groups on the basis of electrophysiologic criteria: type 1 is the demyelinating form, and type 2 the axonal form Charcot-Marie-Tooth (CMT) disease is a group of disorders in which the motor and/or sensory peripheral nerves are affected, resulting in muscle weakness and atrophy as well as sensory loss. Symptoms occur first in the distal legs and later in the hands. The nerve cells in individuals with this disorder are not able to send electrical signals.

Charcot-Marie Tooth disease (CMT) Clinical Features Foot drop (usually the initial symptom) High stepped gait Frequent falls Hammer toes, high arched feet ( pes cavus) or flat arched feet (pes planus) are classical Muscle wasting Weakness in legs later progresses to hands and forearms Difficulty with fine motor skills Claw hand Charcot-Marie-Tooth syndrome is an inherited disease that can be passed from generation to generation. In America, it affects around 150,000 people. It is a worldwide disorder that can affect anyone. The disorder was discovered in 1886 by three doctors, Jean-Martin Charcot, Pierre Marie, and Howard Henry Tooth Charcot Marie tooth disease follows an autosomal pattern in the most number of cases which can be dominant or recessive depending upon the type of CMT disease. Since the CMT disease type 1 and 2 are the most common among all, it follows an autosomal dominant pattern of inheritance. A few cases of X linked inheritance has also been reported

Charcot-Marie-Tooth disease (CMT) is the most frequent form of inherited neuropathy with great variety of phenotypes, inheritance patterns, and causative genes. According to median motor nerve conduction velocity (MNCV), CMT is divided into demyelinating (CMT1) with MNCV below 38 m/s, axonal (CMT2) Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Martin Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England 16q22.1. Charcot-Marie-Tooth disease, axonal, type 2N. 613287. Autosomal dominant. 3. AARS1. 601065. TEXT. A number sign (#) is used with this entry because this form of axonal Charcot-Marie-Tooth disease type 2, here designated CMT2N, is caused by heterozygous mutation in the AARS gene (AARS1; 601065) on chromosome 16q22 Charcot-Marie-Tooth (CMT) disease is the most prevalent inherited neuropathy. Today more than 40 CMT genes have been identified. Diagnosing heterogeneous diseases by conventional Sanger sequencing is time consuming and expensive. Thus, more efficient and less costly methods are needed in clinical diagnostics. We included a population based sample of 81 CMT families If you have Charcot-Marie-Tooth disease, regular stretching can prevent or reduce joint deformities that may result from uneven pulling of muscle on your bones. Exercise daily. Regular exercise keeps your bones and muscles strong. Low-impact exercises, such as biking and swimming, are less stressful on fragile muscles and joints

Inheritance of Charcot-Marie-Tooth Disease - CMTAR. Charcot-Marie-Tooth (CMT) disease is a group of genetic disorders that cause defects in the myelin sheaths (the insulating material that prevents the loss of electrical signals as they travel along nerve fibers), or the axons themselves (the nerve cell extension), in the peripheral nervous. Charcot-Marie-Tooth disease Description Charcot-Marie-Tooth disease encompasses a group of disorders called hereditary sensory and motor neuropathies that damage the peripheral nerves. Peripheral nerves inheritance is dominant if one copy of the altered gene is sufficient to cause the condition. In most cases, affected males, who have the.

Charcot-Marie-Tooth Disease (CMT) Our genetics counselor will carefully review the history of disease with each family, discuss the principles of inheritance and help weigh risks and benefits of genetic testing of various family members Charcot-Marie-Tooth disease (CMT) is a spectrum of nerve disorders named after the three physicians who first described it in 1886 — Jean-Martin Charcot and Pierre Marie of France and Howard Henry Tooth of the United Kingdom. The term CMT is regarded as being synonymous with hereditary motor sensory neuropathy (HMSN) X-linked inheritance). hOver 90% of patients with Charcot-Marie-Tooth disease have a mutation in the PMP22, MFN2, MPZ,orGJB1 gene. hAn autosomal dominant mutation can occur de novo in a patient. hEach child of a parent with an autosomal dominant neuropathy has a 50% chance of inheriting the disease. hA father who has Charcot-Marie-Tooth disease. Important Research News Announcements. Natural history of Charcot-Marie-Tooth disease type 2A: a large international multicentre study January 9, 2021; Epigenetic Regulation of CMT: A Lesson from Drosophila Models January 7, 2021; Clinical features of homozygous FIG4-p.Ile41Thr Charcot-Marie-Tooth 4J patients January 6, 2021; Aberrant Splicing in GJB1 and the Relevance of 5′ UTR in CMTX1.

Charcot-Marie-Tooth: From Molecules to Therap

  1. Charcot-Marie-Tooth disease (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body. This disease is the most commonly inherited neurological disorder affecting about one in 2,500 people
  2. ant, autosomal recessive, or X
  3. Patients with Charcot-Marie-Tooth (CMT) disease have a significant family history. This history varies depending on the inheritance and penetrance pattern of the particular disorder (see Etiology ). Spontaneous mutations also have been reported. The age of presentation varies, depending on the type of CMT disease
  4. ant, recessive, or X-linked) and whether the primary pathology is located in the myelin or axon. From: Electromyography and Neuromuscular Disorders (Third Edition), 2013
  5. classification is based on inheritance patterns and molecular genetics 1,2. 5 main types include Charcot-Marie-Tooth type 1 (CMT1), CMT2, CMT3 (or intermediate form), CMT4, and CMTX ; subtypes of CMT are based on mutations in specific genetic loc
  6. g and expensive. Thus, more efficient and less costly methods are needed in clinical diagnostics. We included a population based sample of 81 CMT families
  7. Charcot-Marie-Tooth (CMT) disease is a hereditary neuropathy with many types and subtypes, including types 1 (CMT1), 1A (CMT1A), 2 (CMT2), and 4 (CMT4), among others. Disorders with similar clinical findings include hereditary motor neuropathy (HMN), hereditary motor and sensory neuropathy (HMSN), hereditary sensory neuropathies (HSN.

Classifications of Charcot-Marie-Tooth disease refers to the types and subtypes of Charcot-Marie-Tooth disease (CMT), a genetically and clinically heterogeneous group of inherited disorders of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body. CMT is a result of genetic mutations in a number of genes CHARCOT-MARIE-TOOTH disease (CMT) type 2 or hereditary motor and sensory neuropathy type 2 is a genetically heterogeneous group of axonal neuropathies with motor and sensory abnormalities and signs of axonal degeneration on electrodiagnostic investigation and in sural nerve biopsy specimens. 1-3 Age of onset varies between the first and seventh decades of life, and the disease in asymptomatic. Charcot-Marie-Tooth (CMT) disease is the most common inherited neuromuscular disorder. It is characterized by inherited neuropathies without known metabolic derangements. [ 1, 2] These disorders are also known as hereditary motor and sensory neuropathies (HMSNs); they are distinct from hereditary sensory neuropathies (HSNs) and hereditary motor.

About Charcot-Marie-Tooth Disease Charcot-Marie-Tooth disease (CMT) is an inherited neurological disease characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand, and forearm, and a mild loss of sensation in the limbs, fingers, and toes Charcot Marie tooth disease is an inherited disorder with autosomal dominant inheritance as its major pattern. It involves sensory and motor nerves at their periphery due to demyelination disease caused by a defective gene synthesizing the myelin

Charcot-Marie-Tooth Disease Fact Sheet National

Inheritance: How likely is Charcot-Marie-Tooth disease to

Charcot-Marie-Tooth disease. Dr Bahman Rasuli and Assoc Prof Frank Gaillard et al. Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor and sensory neuropathy ( HMSN ), is the most commonly inherited neuropathy of lower motor (to a lesser degree sensory) neurons. On this page CMT is an inherited peripheral neuropathy - a person must have a peripheral neuropathy based on a nerve conduction test in order to be affected with the condition. Genetic testing can also be done in order to identify a specific sub-type of CMT. Once a sub-type is identified in the family, other family members may just need the nerve conduction.

What is Charcot-Marie-Tooth Disease? - The Unchargeables

The gene encoding ganglioside-induced differentiation-associated protein 1 is mutated in axonal Charcot-Marie-Tooth type 4A disease. Nat Genet 2002; 30:22. Pedrola L, Espert A, Wu X, et al. GDAP1, the protein causing Charcot-Marie-Tooth disease type 4A, is expressed in neurons and is associated with mitochondria Collectively the Charcot-Marie-Tooth (CMT) neuropathies are the most common cause of hereditary neuropathy with a prevalence of approximately 1 in 2500. Charcot-Marie-Tooth neuropathies are also known as hereditary motor and sensory neuropathies (HMSN) because they are characterized by predominately motor and sensory symptoms

Charcot-Marie-Tooth Disease(s) Hereditary Ocular Disease

  1. CMT & Genetic Mutations Charcot-Marie-Tooth disease is caused by inherited mutations in the genes involved with the structure and function of the peripheral nerves Chromosome 17 PMP22 gene duplication PMP22 gene duplication 18
  2. Charcot-Marie-Tooth disease ( CMT )causes motor and sensoryneuropathies of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body. 8. What is the inheritance pattern shown? 9. Provide at least one piece of evidence for your claim. 10
  3. Test description. The Invitae Charcot-Marie-Tooth Disease Comprehensive Panel analyzes genes associated with Charcot-Marie-Tooth disease (CMT), a group of hereditary neuropathies characterized by progressive muscle weakness and sensory loss in the arms and legs.These genes were curated based on currently available evidence to provide a comprehensive test for the genetic causes of CMT
  4. Charcot Marie Tooth Disease (CMT), aka peroneal muscular atrophy, causes weakness and loss of sensation in the feet, legs and hands. CMT is the most common inherited neurological disorder and affects approximately 1 in every 2,500 people. Charcot Marie Tooth Disease was first identified in 1886 by three doctors, Jean-Marie Charcot, Pierre Marie.

Charcot-Marie-Tooth disease - Symptoms and causes - Mayo

Charcot-Marie-Tooth disease (CMT) is an inherited autosomal dominant trait that occurs in about 1/25,000 individuals and is characterized by atrophy of the muscles in the legs, progressing over time to the hands, forearms, and feet. There are two clinical classes of CMT: type I and type II Charcot-Marie-Tooth disease (CMT) The motor nerves carry messages from the brain and spinal cord to our muscles, telling them to contract. The sensory nerves convert specific external stimuli, such as touch and pain, into signals that are transmitted back to the brain. CMT causes the motor and sensory nerves to become damaged and eventually die Most types of Charcot-Marie-Tooth disease are usually inherited as an autosomal (not sex-linked) dominant trait. That is, only one gene from one parent is required for the disease to develop. However, some forms can be inherited as a recessive trait (requiring two genes, one from each parent) or sex (X)-linked. In sex-linked inheritance, the. Charcot Marie Tooth Disease: Definition Charcot Marie Tooth disease (CMT) is the name of a group of inherited disorders of the nerves in the peripheral nervous system (nerves throughout the body that communicate motor and sensory information to and from the spinal cord) causing weakness and loss of sensation in the limbs. Description CMT is.

Inheritance patterns - Charcot-Marie-Tooth U

Charcot-Marie-Tooth disease (CMT) 1,2 is the most common inherited peripheral neuropathy, with a frequency of 1 in 2500, 3 and is one of the most prevalent autosomal dominant diseases 4.It is a. ckniffin : 01/05/2021. # 500013. CHARCOT-MARIE-TOOTH DISEASE, AXONAL, MITOCHONDRIAL FORM, 1; CMTMA1. TEXT. A number sign (#) is used with this entry because of evidence that mitochondrial form of axonal Charcot-Marie-Tooth disease-1 (CMTMA1) is caused by mutation in the MTTV gene (590105), which is encoded by the mitochondrial genome

Charcot-Marie-Tooth disease, a genetic nerve condition that primarily affects the feet and hands, may have no cure, but it can be managed with physical therapy and attention to care. Find out more. Search for: Rare Disease Profiles; 5 Facts; Rare IQ; Rare Mystery; Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal.

Charcot-Marie-Tooth (CMT) disease encompasses a heterogeneous group of inherited, severe, debilitating, progressive and chronic peripheral neuropathies.Charcot-Marie-Tooth disease type 1A (CMT1A), the most common type of CMT, is an orphan disease with a prevalence of 1/5000 people affecting at least 150,000 people in Europe and the U.S. and about 1,500,000 people worldwide The Charcot Marie Tooth (CMT) market report gives the thorough understanding of the CMT by including details such as disease definition, symptoms, types, causes, genetics and inheritance. Definition. An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and. Charcot Marie Tooth disease (CMT): Any type of a hereditary peripheral neuropathy. Chromosome: In X-linked inheritance, the sex of the person who is affected matters in terms of the risk to the children of that person's chance of having inherited the condition. Females have two X chromosomes, and males have an X and a Y chromosome Patients with Charcot-Marie-Tooth disease type 2F (CMT2F) have slow progression and worse distal weakness. In 2001, Ismailov et al reported a 6-generation family with autosomal dominant CMT of the.

Inheritance of Charcot-Marie-Tooth disease 1A with rare nonrecurrent genomic rearrangement. Byung-Ok Choi 1, Nam Keun Kim 2, Sun Wha Park 3, Young Se Hyun 3, Hyeon Jeong Jeon 3, Jung Hee Hwang 4 & Ki Wha Chung 3 neurogenetics volume 12, pages 51-58 (2011)Cite this articl Charcot-Marie-Tooth disease is an inherited disorder, which means it runs in families. Therefore, people with a family history of CMT are at a higher risk of developing the disease. Most types of CMT are caused by defects in genes that affect two specific parts of nerves: axons and myelin Charcot-Marie-Tooth disease is an inherited peripheral neuropathy with two forms: a demyeli - nating form (type 1) affecting the glia-derived myelin and an axonal form (type 2) affecting the nerve axon. The two forms can be distinguished by means of electrophysiological or neuropatho-logical studies. Charcot-Marie-Tooth disease ha

Charcot-Marie-Tooth (CMT) disease is one of the hereditary motor and sensory neuropathy (HMSN) disorders, a group of genetically based disorders characterized by progressive motor weakness, decreased nerve conduction velocities, and nerve root enlargement ().Although these disorders are most often diagnosed clinically, MR and CT imaging in these patients is being used more frequently Charcot-Marie-Tooth disease is an inherited peripheral neuropathy with two forms: a demyelinating form (type 1) affecting the glia-derived myelin and an axonal form (type 2) affecting the. Charcot-Marie-Tooth (CMT) disease is a heterogeneous group of genetic disorders presenting with the phenotype of a chronic progressive neuropathy affecting both the motor and sensory nerves Hereditary Sensory > Motor Ulcero-Mutilating Neuropathy (HSN2C) Epilepsy, generalized: Ala397Asp, Dominant 158. Similar to: Axonal CMT (CMT2) with Acrodystrophy, Recessive. Interacts with the domain Encoded by HSN2 Exon of WNK1. Anterograde transport of synaptic-vesicle (SV) precursors along axons

Inheritance of Charcot-Marie-Tooth Disease - Charcot-Marie

Charcot-Marie-Tooth (CMT) is a genetic nerve disease with over 100 known genetic causes. Onset can be at birth or later in life and is characterized by degeneration of motor nerves and loss of sensation in the feet, hands, legs and arms. CMT is a progressive disease that can lead to severe disability or even death Charcot-Marie-Tooth disease (CMT) is the commonest inherited neuromuscular disorder. It affects the peripheral nerves and leads to progressive weakness of extremities. Occasionally it involves cranial nerves, other sites of the neuraxis, and other organ systems PMP22 related neuropathies can be divided in three groups. The first group is caused by a PMP22 duplication, and constitutes the majority of Charcot-Marie-Tooth disease type 1A (CMT1A). The second group is caused by a PMP22 deletion, leading to Hereditary Neuropathy with liability to Pressure Palsies (HNPP). The third group is composed of neuropathies related to point mutations in the PMP22.

Classification Of Charcot Marie Tooth Disease

Charcot-Marie-Tooth disease type 1A Genetic and Rare

Classification of Charcot-Marie-Tooth Disease

Despite what the name may sound like, Charcot-Marie-Tooth disease (also called CMT disease) has nothing to do with your teeth. CMT disease is actually an inherited neurological disorder named after the three doctors who first identified the disease in the 1880s: Jean-Martin Charcot, Pierre Marie and Howard Henry Tooth Objectives: To determine the genetic distribution and the phenotypic correlation of an extensive series of patients with Charcot-Marie-Tooth disease in a geographically well-defined Mediterranean area. Methods: A thorough genetic screening, including most of the known genes involved in this disease, was performed and analyzed in this longitudinal descriptive study Charcot-Marie-Tooth disease is the most common hereditary neuropathy, affecting about 1 of 2,500 people. It may begin during childhood or later in life. Charcot-Marie-Tooth disease is a sensory and motor neuropathy. That is, it affects motor nerves (which control muscle movement) and sensory nerves (which carry sensory information to the brain) Charcot-Marie-Tooth (CMT) disease or hereditary motor and sensory neuropathy (HMSN) is a genetically heterogeneous group of conditions that affect the peripheral nervous system. The disease is characterized by degeneration or abnormal development of peripheral nerves and exhibits a range of patterns of genetic transmission. In the majority of cases, CMT first appears in infancy, and its. This is the first case report of adult-onset CMT2A with an autosomal-recessive inheritance pattern. The phenotype caused by the MFN2 mutation in these cases is very mild, considering that the mutation causes middle-aged-onset Charcot-Marie-Tooth even in the homozygous state

Charcot-Marie-Tooth Disease - Hopkins Medicin

Charcot-Marie-Tooth disease type 2P Genetic and Rare

Charcot-Marie-Tooth (CMT) disease is the most common form of inherited peripheral neuropathy, and these conditions have a prevalence of approximately 1 in 3000 individuals. Clinical symptoms include distal muscle weakness with atrophy, loss of deep tendon reflexes, high-arched feet, and loss of sensation Charcot Marie Tooth disease includes all inherited peripheral neuropathies. These are conditions that can be passed on from generation to generation that cause problems with the nerves that go from the spine to the feet and hands. Main features include foot drop (difficulty pulling the foot towards the head) and hand weakness Background Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous group of diseases with approximately 45 different causative genes described. The aims of this study were to determine the frequency of different genes in a large cohort of patients with CMT and devise guidelines for genetic testing in practice. Methods The genes known to cause CMT were sequenced in. Shaheen Lakhan, MD, PhD, is an award-winning, board-certified physician-scientist and clinical development specialist. Charcot-Marie-Tooth disease (CMT) represents a group of disorders that cause defects in the nerves of your arms and legs. These nerve defects can go on to cause muscle weakness, atrophy, and sensory loss

Charcot-Marie-Tooth (CMT) is a group of genetically inherited diseases that result in nerve damage to peripheral nerves in the legs and arms resulting in an inability to properly use the muscles in these areas. Usually appearing in adolescence or early adulthood, someone with CMT may have smaller and weaker muscles of the arms and legs, loss of. Charcot-Marie-Tooth Disease (CMT) is also referred to as, 'Hereditary Motor and Sensory Neuropathy,' or, 'Peroneal Muscular Atrophy.'. CMT is a group of hereditary conditions. CMT is marked by a slow progression of weakness in the person's muscles, as well as, 'atrophy,' or wasting in their feet, lower legs, forearms and hands sfhill01. Neuro: Charcot Marie Tooth. What are the two main categories of her. aka hereditary motor and sensory neurop. what is the most common inherited disor. CMT initially involves ____ nerve, and. primary disorder, part of a greater multisystem disorder Charcot-Marie-Tooth disease (CMT) is a genetic, or inherited neurological condition. It affects the nervous system, and specifically the peripheral nervous system. This system relays messages between the brain and body parts. It consists of nerves in the brain and the spinal cord and enables your body to act, both voluntarily (when your brain.

Charcot–Marie–Tooth Disease and Related Disorders | Neupsy Key

Types of Charcot-Marie-Tooth Disease (CMT) - Diseases

The Charcot Marie Tooth (CMT) market report gives the thorough understanding of the CMT by including details such as disease definition, symptoms, types, causes, genetics and inheritance, pathophysiology, and diagnosis Charcot-Marie-Tooth Disease. Charcot-Marie-Tooth disease (CMT) or hereditary motor and sensory neuropathy constitutes a genetically heterogeneous group of diseases that affect the peripheral nervous system. CMT is characterized by degeneration or abnormal development of the peripheral nerve and is transmitted with different genetic patterns Charcot-Marie-Tooth disease (CMT) is a group of inherited conditions that damage the peripheral nerves. It's also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy (PMA). The peripheral nerves are found outside the main central nervous system (brain and spinal cord)

Charcot-Marie-Tooth disease is a genetic neurological disorder characterized by weakness and atrophy of muscles first in the legs and, later, in the arms and hands. Founded in 1983, the association acts as an advocate for people with Charcot-Marie-Tooth disease by raising awareness and encouraging public and private agencies and private. Charcot-Marie-Tooth (CMT) disease is the most prevalent peripheral inherited neuropathy (1/2500 to 10 000; 2.8/10 000 in Spain), and the mean age at onset is 16 years (range 2 to 50 years, but presentation in the early infancy and as late as the 80's has been reported)

(PDF) Charcot-Marie-Tooth Disease: Seventeen Causative GenesPPT - Charcot-Marie-Tooth Disease PowerPoint PresentationModes of inheritance-Dr[PDF] Charcot-Marie-Tooth Disease and Other Genetic