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MODY types

HNF1A (MODY3) is the most common form of MODY. It is inherited and generally shows up early in life. Insulin is usually not immediately needed for treatment, as this disorder responds well to sulfonylureas. GCK (MODY2) is the second most common type overall of MODY Neonatal diabetes mellitus (NDM) and maturity-onset diabetes of the young (MODY) are the two main forms of monogenic diabetes. NDM occurs in newborns and young infants. MODY is much more common than NDM and usually first occurs in adolescence or early adulthood. Most cases of monogenic diabetes are incorrectly diagnosed The most common types of MODY are: HNF1-alpha. This gene causes about 70 per cent of cases of MODY. It causes diabetes by lowering the amount of insulin made by the pancreas

In type 1, the pancreas cannot make and release enough insulin. People with type 2 diabetes, on the other hand, usually make enough insulin, but their bodies cannot respond to it effectively (known as insulin resistance). Type 2 diabetes is usually associated with being overweight, but that is not true of type 1 diabetes or MODY Maturity-onset diabetes of the young (MODY) is a rare kind of diabetes that runs in families. Like type 1 and type 2 diabetes, MODY affects the way your body uses and stores sugar from food. But..

Of these 11 known types, there are 4 genes that account largely for most of these types, as described by The British Diabetic Association (TBDA). Most types of MODY are expected to gradually worsen, requiring gradual increases in medications and eventually insulin for some. Let's take a closer look. MODY 1, 3, 4 (HNF1-alpha gene The purpose of this overview is to increase the awareness of clinicians regarding maturity-onset diabetes of the young (MODY) and its genetic causes and management. The following are the goals of this overview: Goal 1: Describe the clinical characteristics of MODY. Goal 2: Review the genetic causes of MODY Type 1.5 patients usually face a lower risk for heart problems than type 2 patients who have the characteristic high cholesterol and blood pressure. Maturity-Onset Diabetes of the Young (MODY) Some younger people develop Maturity-Onset Diabetes of the Young (MODY) - a genetically inherited, rare form of type 2 diabetes caused by a defect in a. MODY (maturity-onset diabetes of the young) and LADA (latent autoimmune diabetes in adults) are two prime examples. They share some features of type 1 and type 2, but also have their own symptoms..

MODY is a rare cause of diabetes (1% of all cases) and is frequently misdiagnosed as Type 1 diabetes (T1DM) or Type 2 diabetes (T2DM). A precise molecular diagnosis is essential because it leads to optimal treatment of the patients and allows early diagnosis for their asymptomatic family members MODY stands for Maturity-onset diabetes of the young and was given that name in the past because it acted more like adult type of diabetes (Type 2 Diabetes) but was found in young people. MODY limits the body's ability to produce insulin, but is different than the juvenile type of diabetes (Type 1 Diabetes)

There are eleven different types of MODY caused by changes in eleven different genes. Treatment varies, depending on the type of MODY. For example, MODY 2 can usually be managed by eating right and exercising regularly. MODY 1, 3, and 4 can usually be managed with a type of medicine called sulfonylurea therapy The different types of MODY are distinguished by their genetic causes. The most common types are HNF1A -MODY (also known as MODY3), accounting for 50 to 70 percent of cases, and GCK -MODY (MODY2), accounting for 30 to 50 percent of cases The longer a person has Type 2 diabetes, the more likely that insulin production will decrease over time. Type 2 diabetes is treated with lifestyle changes, pills, injectable medication and insulin. Today, more and younger people are being diagnosed with Type 2 diabetes. MODY, or maturity-onset diabetes of the young, is caused by a gene mutation Maturity-Onset Diabetes of the Young (MODY) Maturity-onset diabetes of the young or MODY is considered by many physicians and researchers to be a subset of Type 2 diabetes (T2D) and is often misdiagnosed as T2D The stocky body type is a good example of this. Technically speaking, the stocky body type doesn't neatly fall into any of the three body type categories. Although this body type is most similar to the endomorphic body type, it's not exactly synonymous with it. Stocky men are shorter than average with broad shoulders and hips

MODY: One of Several Hereditary Forms of Diabete

Monogenic Diabetes (Neonatal Diabetes Mellitus & MODY) NIDD

MODY 1 (HNF4A gene), MODY 3 (HNF1A gene): people with these types of MODY usually oral sulfonylureas (pills) to lower their blood glucose; 30-40% of people will eventually need to also take insulin to keep their blood sugar in-range hnf1a-mody (mody 3) Diabetes caused by mutations in the HNF1-alpha gene (encoding hepatocyte nuclear factor-1 alpha) is one of the most common types of MODY. This gene contains is a blueprint for a transcription factor that is important in for the normal development of beta cells The most common types are HNF1A-MODY (also known as MODY3), accounting for 50 to 70 percent of cases, and GCK-MODY (MODY2), accounting for 30 to 50 percent of cases. Less frequent types include HNF4A-MODY (MODY1) and renal cysts and diabetes (RCAD) syndrome (also known as HNF1B-MODY or MODY5), which each account for 5 to 10 percent of cases If you're like many people, you may answer the question What's your body type? with a response like hot, weak, strong, flabby, curvy, or another adjective based on your subjective.. MODY is caused by a change in a single gene. Mutations in the genes listed below account for 87% of the UK MODY. HNF1A. HNF4A. GCK MODY. HNF1B MODY . KCNJ11 & ABCC8 MODY . Maternally Inherited Diabetes And Deafness (MIDD) Changes in these different genes lead to different types of MODY

Maturity onset diabetes of the young (MODY) Diabetes U

- ADA classification DM - MODY common gene mutations - Clinical features distinguishing T1DM T2DM MODY - Pancreatic diabetes - Drug-induced diabetes RELATED TOPICS. Patient education: Type 1 diabetes: Overview (Beyond the Basics) Patient education: Type 2 diabetes: Overview (Beyond the Basics Maturity-onset diabetes of the young (MODY) is the most common type of monogenic diabetes, being characterized by beta-cell disfunction, early onset, and autosomal dominant inheritance. Despite the rapid evolution of molecular diagnosis methods, many MODY cases are misdiagnosed as type 1 or type 2 diabetes. High costs of genetic testing and limited knowledge of MODY as a relevant clinical.

The Main Diabetes Types. Type 1 diabetes. LADA. Type 2 diabetes. Gestational diabetes. MODY. Type 3c / Pancreatogenic / Cystic fibrosis-related diabetes (CFRD) / Pancreatitis / Pancreatic cancer. Special forms / surgical / drug induced / etc. Type 3 diabetes Types of MODY. There are five known types of MODY: HNF1-Alpha - This is the most common form of MODY, responsible for 70% of all cases. The amount of insulin produced by the pancreas decreases as a patient ages, as MODY develops during adolescence or early twenties. Generally, this type of MODY doesn't require insulin MODY 5 is a form of diabetes caused by a mutation of a single gene. The mutation causes pancreatic beta cells to function abnormally, leading to insufficient production of insulin. In some cases, insulin resistance develops. In addition, the pancreas may not produce enough digestive enzymes

Maturity Onset Diabetes of the Young (MODY) - Harvard Healt

another type of diabetes that occurs in children and young

Maturity-Onset Diabetes of the Young (MODY): Causes

What does Maturity-Onset Diabetes of the Young (MODY) look like?. Determining which type of diabetes a patient has is critical in providing the proper care and treatment. However, a rise in childhood obesity has made distinguishing between type 1 and type 2 diabetes increasingly more challenging. 4 Additionally, MODY is often misdiagnosed as Type 1 or Type 2 diabetes due to the similarities in. Diabetes mellitus with autosomal dominant inheritance, such as maturity-onset diabetes of the young (MODY), is a genetic form of diabetes mellitus. MODY is a type of monogenic diabetes mellitus in which multiple genetic variants may cause an alteration to the functioning of beta cells. The three most known forms of MODY are caused by modifications to the hnf4a, gck, and hnf1a genes MODY genes have distinct mechanisms of action and phenotypic presentations compared with type 1 and type 2 DM and other forms of DM. Healthcare professionals are therefore advised to formulate drugs and treatment based on the causal genes rather than the current generalized treatment for all types of DM MODY is a monogenic form of nonautoimmune diabetes mellitus that often manifests in adolescents or young adults, usually before age 30. 14-18 It is estimated to account for 1% to 2% of all patients with diabetes. 11,15,24 Whereas MODY is widely classified as a separate type of diabetes, 11 each time a clinician sees a patient with type 2.

MODY Diabetes: Everything You Need to Know Diabetes Stron

In type 1 diabetes the pancreas won't be able to produce insulin but in type 2 diabetes insulin produced by the pancreas is not enough. Diabetes MODY constantly gets confused with both types. Types of Diabetes MODY: There are 11 different MODY types- Mody 1 to 11. Causes of MODY: MODY is also known as a monogenic disease. It is caused due to. Maturity-onset diabetes of the young type 5 (MODY 5) is a form of monogenic diabetes that is often accompanied by pancreatic dysfunction. To date, no cases of MODY 5 treated with glucagon-like peptide-1 receptor agonist (GLP-1RA) have been reported. We present the first case of MODY 5 treated with GLP-1RA Type 1 diabetes is the second most common - approximately 15% of people with diabetes in the UK have type 1. There are also other less common types of diabetes including gestational diabetes, LADA and MODY. The risk of type 2 diabetes increases with age, meaning that most people who develop type 2 diabetes are usually middle aged or older

MODY, or Maturity Onset Diabetes of the Young, is a rare form of diabetes that is genetic in onset. Only about 1% of people with diabetes have MODY. This form of diabetes is so rare, that often times practitioners misdiagnose people with either type 1 or type 2 initially. MODY is caused by a mutation of a single gene; if a parent has MODY, their child has a 50% chance of inheriting the. One of the less common causes of MODY is the mutation in the hepatocyte nuclear factor 1 beta (HNF1B) gene, the well-recognized cause of MODY type 5 (MODY5), which accounts for 5% to 10% of all MODY cases [5,8]. MODY5 develops during adolescence or early adulthood MODY is a rare form of diabetes which is different from both type 1 and type 2 diabetes, and runs strongly in families. MODY is caused by a mutation (or change) in a single gene. If a parent has this gene mutation, any child they have, has a 50 per cent chance of inheriting it from them

Maturity-Onset Diabetes of the Young Overvie

Get to know the various types of diabetes and learn to differentiate between type 1, type 2, and gestational diabetes. Diabetes mellitus , type 1 versus type 2 diabetes , symptoms of gestational diabetes , diabetes due to viral infection , MODY diabetes . Read more here This is a late onset Type 1 diabetes or LADA (Latent Autoimmune Diabetes in Adults), which is initially misleading. It is thought that a little over 3% of people diagnosed with Type 2 diabetes may actually have Type 1 diabetes. MODY diabetes (Maturity Onset Diabetes of the Young) MODY is a rare form of diabetes with a known genetic.

Other Forms (MODY, LADA, Neonatal) DiabetesCare

610508. 3. KLF11. 603301. TEXT. A number sign (#) is used with this entry because of evidence that maturity-onset diabetes of the young type 7 (MODY7) is caused by heterozygous mutation in the KLF11 gene (603301) on chromosome 2p25. For a phenotypic description and a discussion of genetic heterogeneity of MODY, see 606391 A number sign (#) is used with this entry because of evidence that maturity-onset diabetes of the young type 6 (MODY6) is caused by heterozygous mutation in the NEUROD1 gene on chromosome 2q31.For a general phenotypic description and a discussion of genetic heterogeneity of MODY, see 606391. Molecular Genetic Maturity onset diabetes of the young (MODY) is an autosomal dominant mutation leading to non-insulin dependent diabetes mellitus. First described in 1976, it has an early onset and is prevalent in 1-2% of type 2 diabetics

Maturity-onset diabetes of the young (MODY) is a type of monogenic diabetes first described as a mild and asymptomatic form of diabetes that was observed in non-obese children, adolescents, and young adults. Improvement in blood glucose levels has been observed with sulfonylurea treatment MODY is a monogenic, dominantly inherited form of diabetes that typically arises in adolescence or young adulthood, and accounts for 1-4% of cases of pediatric diabetes MODY is a rare form of diabetes which is different from both type 1 and type 2 diabetes, and runs strongly in families. MODY is caused by a mutation (or change) in a single gene. If a parent has this gene mutation, any child they have, has a 50% chance of inheriting it from them Maturity-onset diabetes of the young (MODY) is a group of monogenic forms of diabetes that exhibit specific loss-of-function mutations with characteristic phenotypes.Thus far, 11 different MODY forms have been described ().These are due to mutations in single genes for transcription factors and genes for insulin and proteins involved in insulin secretion, β-cell mass, and glucose metabolism Commentary. MODY is a type of diabetes characterized by early onset before the age of 25 years in nonobese individuals with an absence of pancreatic β-cell antibodies ().There are currently 13 genes associated with this disorder and 13 types of MODY for each of these genes ().Inheritance is autosomal dominant with 85-95% penetrance, and patients are usually heterozygous for these mutations.

HNF4A diabetes is one of a group of familial diabetes types called maturity onset diabetes of the young (MODY). What can we say about MODY caused by changes in HNF4A? The diabetes caused by HNF4A tends to occur in childhood or early adulthood although some people may not be diagnosed until middle or old age. There is often an increasing need. These Mendelian subtypes include neonatal diabetes, maturity-onset diabetes of the young (MODY), and syndromic forms. Genetics also plays a role in Type 1 and 2 diabetes, the most common types of diabetes, but the etiology is polygenic, with variants in dozens of genes, each with a small effect, collectively increasing a person's risk of disease I will focus on Type 1, Type 2, LADA, Type 3c, and MODY/NDM simply because Gestational diabetes is routinely tested for and Type 0 presents very differently to the other Types and is more easily diagnosed. I will also assume, like many of us, the patient has presented with a mild DKA for the first time e.g. thirsty, peeing a lot, lethargy.

MODY can sometimes be controlled more effectively than other types of diabetes. Treatment of MODY 2 is only about the use of an appropriate diet. In the MODY 3 type, due to the high sensitivity to sulfonylurea derivatives, it is possible to successfully use these drugs for many years Hver type skyldes en ændring (en mutation) i ét af 13 gener. Fælles for de fleste MODY-former er, at kroppen ikke producerer nok insulin, men det, den producerer, virker fint. Dette er modsat type 2-diabetes, hvor man ofte producerer nok insulin, men hvor insulinet ikke virker optimalt. MODY kræver derfor ikke altid insulinbehandling PubMed ID: 23760703). In the UK, HNF1A-MODY is the most common form in adults while GCK-MODY is the most common form in children. In a large genomic screen study of 4,016 patients diagnosed with type 2 diabetes, nearly 2% of patients with early onset (<40 years) disease were found to have pathogenic variants in MODY genes (Bansal et al. 2017 The most common type of monogenic diabetes is maturity-onset diabetes of the young (MODY), a clinically and genetically heterogeneous group of endocrine disorders that affect 1-5% of all patients with diabetes mellitus. MODY is characterized by autosomal dominant inheritance but de novo mutations have been reported. Clinical features of MODY include young-onset hyperglycemia, evidence of. Introduction. Maturity onset diabetes of the young (MODY) is a monogenic form of diabetes, caused by variation in a single gene, and type 1 (T1DM) and type 2 diabetes mellitus (T2DM) are polygenic in nature

LADA (Type 1.5) and MODY Diabetes: Symptoms and Treatmen

  1. We offer testing for maturity-onset diabetes of the young (MODY), the most common type of monogenic diabetes, as well as neonatal diabetes mellitus (NDM), a rarer form. 3 Many pediatric patients with MODY are mistakenly diagnosed with type 1 diabetes, whereas older patients with MODY (in their 20s and 30s) are often thought to have type 2.
  2. ant inheritance, and absence of insulin dependence. The most frequent subtypes are due to mutations of the GCK (MODY 2), HNF1A (MODY 3), and HNF4A (MODY 1) genes. We undertook the first multicenter genetic study of MODY in the Portuguese population
  3. Children with MODY may present as having type 1 diabetes. As they may respond better to oral hypoglycemic agents, recognizing MODY as a possibility is important. Always consider the diagnosis of.

Maturity-onset diabetes of the young (MODY): an updat

  1. Monogenic diabetes is a rare condition resulting from mutations (changes) in a single gene. In contrast, the most common types of diabetes— type 1 and type 2 —are caused by multiple genes (and in type 2 diabetes, lifestyle factors such as obesity). Most cases of monogenic diabetes are inherited
  2. mody type diabetes icd 10 diet plan printable. A well child with hyperglycaemia is likely to have one of four diagnoses: type 1 diabetes (although it is rare to have children with type 1 diabetes present with hyperglycaemia and total lack of ketones); type 2 diabetes; maturity onset diabetes of the young (MODY); or autoimmune diabetes with slow onset
  3. MODY is the most common form of monogenic diabetes with an estimated prevalence at 1:10,000 in adults and 1:23,000 in children. Approximately 80% of cases are misdiagnosed as type 1 or type 2 diabetes, complicating prevalence and incidence estimations
  4. Intended purpose The SALSA MLPA Probemix P241 MODY Mix 1 is an in vitro diagnostic (IVD) 1 or research use only (RUO) semi-quantitative assay 2 for the detection of deletions or duplications in the HNF4A, GCK, HNF1A, and HNF1B genes in order to confirm a potential cause for and clinical diagnosis of Maturity-Onset Diabetes of the Young (MODY) type 1, 2, 3, and 5, respectively, and for.

Diabetes MODY: Causes, Symptoms, Diagnosis and Treatmen

MODY is categorized into 14 known subtypes based on the genes affected. The 2 most common are MODY 2 and MODY 3, which result from defects in the glucokinase and hepatocyte nuclear factor-1α. MODY can often be treated with oral type 2 medication, specifically sulphonyurea, but some people will need insulin. There are up to 15 MODY gene mutations, each is different, and some cause other complications along with diabetes. MODY is often misdiagnosed at type 1 or 2 diabetes, but it could account for up to 5% of diabetes cases

「その他の型」の糖尿病は発症幾序が特定 - だぶるくれーどる

MODY is a monogenic form of diabetes that is often confused with type 1 or type 2 diabetes. MODY decreases the amount of insulin a person's body makes, which in turn limits the body's ability to control the amount of sugar (glucose) in the blood MODY: It is believed that about 1-5% of diabetics have MODY, a heritable form of diabetes whose symptoms can resemble T1D, T2D, or gestational diabetes [6]. Although this form of diabetes is typically associated with childhood or early adulthood, it can affect people of all ages including neonates (a case where it is referred to as neonatal. Not all men are created physically equal, and we have to account for different body types when we talk about getting dressed. To that end, we've put together a collection of articles that detail the ins and outs of various male body types. We have identified nine different body types and two body type modifications: Irregular and Athletic People with MODY have neither type 1 nor type 2 diabetes and often do not require insulin. Depending on the type of MODY, therapy options differ. All of these are examples of unusual forms of diabetes. Researchers currently suspect that many more forms of atypical diabetes may be related to specific gene mutations that cause unusual insulin.

AI and ECG could provide an alternative to finger prick

Maturity Onset Diabetes of the Young (MODY) Guide: Causes

  1. Endomorph Body Type. The endomorph body type is solid and generally soft. Endomorphs gain fat very easily. Endo's are usually of a shorter build with thick arms and legs. Muscles are strong, especially the upper legs. Endomorphs find they are naturally strong in leg exercises like the squat
  2. ant pattern and estimated to account for 1-2% of all.
  3. When this diabetic gets type 2 too, he has to take oral type II medications as well. MODY. Another monogenic form of diabetes is MODY (Maturity-Onset Diabetes Of The Young). This type of diabetes is often diagnosed among teenagers and young adults. In MODY, the body' s inability is due to gene mutation with the genes inherited from one of the.
  4. The entry in Wikipedia says that it is also sometimes called monogenic diabetes and that it is not the same thing as Type 2 diabetes in a young person. My Taber's Cyclopedic Medical Dictionary, on the other hand, defines MODY as type 2 DM that presents during childhood or adolescence. I can't find an entry for it in the ICD-9 index
  5. ant inherited disease, means born with a single (auto) gene that can become from either parent
  6. ant pattern of inheritance, it was quickly suspected that it might be a monogenic dis-order.4 MODY is by far the commonest type of monogenic diabetes
  7. Maturity onset diabetes of the young (MODY) comprises a heterogeneous group of monogenic disorders characterised by β cell dysfunction. It is estimated to be the underlying cause of diabetes in 1-2% of patients diagnosed with diabetes, but prevalence estimates will not be accurate until large population screening studies are performed. 1 It is important to distinguish MODY from type 1 and.

Maturity-onset diabetes of the young: MedlinePlus Genetic

  1. MODY Type 5 is caused by mutation in Hepatocyte nuclear factor 1 beta (HNF1B) gene located on chromosome 17. It is a rare form of MODY that is associated with kidney disease. Hnf-1B plays a major role in kidney development and nephron differentiation and is also a critical regulator of a transcriptional network that controls the specification
  2. We present an update of knowledge on diabetes MODY (maturity onset diabetes of the young), including the recent molecular discoveries, and new diagnostic strategies. Considerable progress has been made in understanding the different molecula
  3. The receiver operating characteristic curve analysis illustrates that a diagnostic threshold of 7 points for the main criteria provided optimal differentiation of patients with MODY from patients with type 1 diabetes (T1D) and type 2 diabetes (T2D), showing a sensitivity of 80.0% and specificity of 94.0% for both T1D and T2D, and the area under.
  4. It's been estimated that as many as 95% of people with MODY have been misdiagnosed with Type 1 or Type 2 diabetes. However, people with MODY are not insulin dependent, and when properly reclassified from Type 1 to MODY have been able to safely transition from insulin to oral medications (with some sources indicating improved management)
  5. Maturity-onset diabetes of the young (MODY) is a rare monogenic form of diabetes and is often misdiagnosed as type 1 diabetes or type 2 diabetes (1,2).A correct genetic diagnosis of MODY is important for predicting the clinical course of disease, risk to relatives, and optimizing treatment
  6. Mody MSP Series- Expanded range from 2.5HP-220HP (1.8 kW-170 kW) 60/50Hz. May 26, 2020. 0 comments. The Mody MSP pumps for wastewater/sewage and storm water are designed for a variety of installations; portable, wet pit and fixed
  7. It depends upon age of child/person, type of MODY, and how easy/difficult control is. Obviously, you should discuss this with your diabetes team since they will know these details and be able to provide specific and individualized advice. Some of the most difficult very young children treated with insulin really have forms of MODY and this is.

Types of diabetes - Mayo Clinic Health Syste

  1. MODY mutations have been found in many different ethnic groups, with glucokinase and HNF-1 alpha being the commonest types by far. In total MODY makes up between 2-5% of patients with Non-Type 1 diabetes. 15% of MODY patients will not have a known MODY mutation; these people are said to have MODY X, and work is continuing to find the gene.
  2. The 14 responsible genes are reported to be MODY type 1~14, of which MODY 2 and 3 might be the most common forms. Although MODY is currently classified as diabetes of a single gene defect, it has become clear that mutations in rare MODYs, such as MODY 5 and MODY 6, have small mutagenic effects and low penetrance
  3. type of MODY may be detected during pregnancy, when glucose tolerance testing is routinely performed. MODY1: Mutations in the hepatocyte nuclear factor-4 alpha (HNF4A) gene cause a clinical presentation similar to HNF1A. However, mutations in this gene are much less common (less than 10% of MODY). Age of onset may be later, and there is no
  4. MODY MODY is an uncommon form of diabetes that accounts for 1% to 5% of all cases in young people. It's a form of monogenic diabetes caused by a genetic defect of the beta cell.3 Various genes are responsible for type 1 and type 2 diabetes, but monogenic forms result from mutations in a single gene
  5. Maturity onset type diabetes of the young (MODY) was previously considered to be a third form of type 2 diabetes. However, with the discovery of specific mutations leading to MODY, it is now classified under secondary or other specific types of diabetes. MODY is characterized by onset prior to age 25
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IA-2, insulinoma-associated antigen-2; MODY, maturity-onset diabetes of the young; Molecular genetic studies of monogenic forms of diabetes such as maturity-onset diabetes of the young (MODY) and neonatal diabetes have provided important insight into the pathophysiology and have led to improved diagnosis and treatment (1-7).In type 1 diabetes, immune-mediated destruction of the pancreatic β. Pursuing accurate diagnosis for minorities with MODY. Accurately diagnosing racial and ethnic minority patients with MODY and entering them in the registry will enable researchers to understand if there are differences in biomarkers or the response to medications in different races. The Monogenic Diabetes Registry is a signal achievement of the. The management of GCK-MODY differs significantly from other types that necessitate treatment for adequate glycemic control and to reduce micro- and macrovascular complications. HNF1A-MODY. HNF1A-MODY (formerly referred to as MODY-3) is the most commonly reported genetic variant, representing 30% to 65% of all MODY cases